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Discovery Pinpoints New Therapeutic Target for Atopic Dermatitis

Photo: Dave Cullen

Researchers from Trinity have discovered a key mechanism underlying bacterial skin colonization in atopic dermatitis, which affects millions around the globe.

Atopic dermatitis (AD, also called commonly eczema) is the most common chronic inflammatory skin disorder in children, affecting 15-20% of people in childhood. During disease flares, patients experience painful inflamed skin lesions accompanied by intense itch and recurrent skin infection.

The bacterium Staphylococcus aureus (S. aureus) thrives on skin affected by AD, increasing inflammation and worsening AD symptoms. Although a small number of therapies are available at present for patients with moderate to severe ...