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Mutation in SARS-CoV-2 Spike Protein Renders Virus Up to Eight Times More Infectious

nyu.edu

Photo: by Vince Dittmer / New York Genome Center

NYU.edu

A mutation in the spike protein of SARS-CoV-2--one of several genetic mutations in the concerning variants that have emerged in the United Kingdom, South Africa, and Brazil--makes the virus up to eight times more infectious in human cells than the initial virus that originated in China, according to research published in the journal eLife.

The study, led by researchers at New York University, the New York Genome Center, and Mount Sinai, corroborates findings that the D614G mutation makes SARS-CoV-2 more transmissible.

"In the months since we initially conducted this study ...