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Antibody Binding-Site Conserved Across COVID-19 Virus Variants

Photo: Kelly Lab/Penn State

A tiny protein of SARS-CoV-2, the coronavirus that gives rise to COVID-19, may have big implications for future treatments, according to a team of Penn State researchers.

Using a novel toolkit of approaches, the scientists uncovered the first full structure of the Nucleocapsid (N) protein and discovered how antibodies from COVID-19 patients interact with that protein. They also determined that the structure appears similar across many coronaviruses, including recent COVID-19 variants -- making it an ideal target for advanced treatments and vaccines. They reported their results in Nanoscale.

"We discovered new features about the ...