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DNA Modifications Could Be Used to Determine the Progression of Severe Liver Disease

Medical Xpress

Photo: Vcpmartin/Wikimedia/ CC BY-SA 4.0

Findings of a national study led by the Translational Genomics Research Institute (TGen), an affiliate of the City of Hope, identify potential biomarkers that might eventually be used to diagnose progressive stages of liver disease.

Researchers identified differences in DNA methylation (DNAm) that accurately predicted different stages of liver fibrosis, scarring of the damaged liver, in as many as 94% of patients with non-alcoholic fatty liver disease (NAFLD), according to the study published in the journal Clinical Epigenetics.

NAFLD is the most common chronic liver disease among Western nations, characterized by ...