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Study Identifies Sulfatase As Potential Drug Target for Inflammatory Bowel Disease and Colorectal Cancer

Medical Xpress

Photo: Pixabay

A new study published in Nature has found that a single sulfatase contributes to the degradation of mucus that protects the intestinal lining, potentially leading to inflammatory bowel disease and colorectal cancer.

The human gut microbiota significantly impacts several aspects of intestinal health and disease, including inflammatory bowel disease (IBD) and colorectal cancer. In the colon, secreted mucus creates a barrier that separates gut microorganisms from the lining of the intestine, preventing close contact that can lead to these conditions.

Some gut bacteria are able to utilize mucin glycoproteins, the main mucus component, as a nutrient ...