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Mitigating Lung Damage, Mortality Due to SARS-CoV-2

Medical Xpress

Photo: DOI: 10.1161/ATVBAHA.121.316925

In a new paper, researchers at the University of Illinois Chicago report that a drug approved for treating patients with autoimmune disease helped to prevent lung damage and death in mice infected with the SARS-CoV-2 virus, which causes COVID-19 in humans.

The results of their study provide strong evidence that inflammatory lung vascular leakage—or leaky lungs—is a key feature of COVID-19 illness. Vascular leakage can be caused by severe inflammation and results in a buildup of fluid in the lungs, which interferes with oxygen uptake. Mice infected with SARS-CoV-2 ...