Exosomal & Non-Exosomal miRNAs May Serve as Biomarkers for HCV-Related Cirrhosis, Liver Cancer
Oncotarget published "Exosomal and non-exosomal miRNA expression levels in patients with HCV-related cirrhosis and liver cancer" which reported that patients with HCV-related cirrhosis are at risk for liver cancer development. For these patients, miRNAs may serve as preclinical markers, which expression levels are deregulated in cancer and which are stable to the damaging factors partly through complex formation with proteins or packaging into exosomes. The second question was whether saliva miRNA expression levels – both exosomal and non-exosomal – are associated with primary liver cancer.
These authors evaluated exosomal and non-exosomal miRNAs – let-7a-5p, -16-5p, -18a-5p, -21-5p, -22-3p, -34a-5p ...