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Genes May Affect the Level of Harmful Bacterial Toxins in the Bloodstream

Medical Xpress

Photo: DOI: 10.1161/JAHA.121.022482

medicalxpress.com

Lipopolysaccharide, a virulence factor produced by bacteria, is a toxin that can cause a systemic inflammation via the circulation. In a recently completed study, genetic markers were discovered which are associated with a heightened lipopolysaccharide level in the blood.

Microbes are part of the human body, and bacteria or their components often end up in the circulation. One such bacterial component is lipopolysaccharide (LPS), which is a toxin. High concentrations of LPS in the blood cause sepsis. Low LPS levels, known as endotoxemia, cause low-grade inflammation. In fact, endotoxemia commonly occurs ...