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Researchers Call for Therapeutics to Treat Cholesterol Cousins Called Ceramides


Photo: Cell Press

Therapeutics that target lipids called ceramides might hold potential for treating cardiometabolic disease, argues a review article published November 5th in the journal Trends in Pharmacological Sciences. The authors summarize the evidence supporting a strong relationship between ceramides and a range of diseases in animals and humans and compare it to the decades of datasets that drove the creation of cholesterol-lowering pharmaceuticals.

“Scientists have a lot to do if we are going to realize the potential of ceramide-lowering therapies,” says senior study author Scott Summers (@ScottSummers339) of the University of Utah College of Health. “Our ...