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Team Develops New Screening Process; Could Lead to Next-Generation Therapeutics for a Broad Spectrum of Diseases

Phys.org

Photo: UCI School of Medicine

Phys.org

A new study led by University of California, Irvine researchers developed a high-throughput screen methodology to identify compounds affect a key G protein coupled receptor (GPCR) rhodopsin (Rh). GPCRs mediate many important physiological functions and are considered to be one of the most effective therapeutic targets for a broad spectrum of diseases, ranging from diabetes to immune system disorders.

The study, titled "Identification of small molecule allosteric modulators that act as enhancers/disrupters of rhodopsin oligomerization," was published in the Journal of Biological Chemistry, and provides a monitoring tool for future investigation of ...