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Scientists Find Additional Molecular Miscues in a Genetic Heart Disorder that Primarily Afflicts Young People

Medical Xpress

Photo: Pixabay

New research involving a devastating genetic heart condition suggests that mutations in adhesion proteins—molecules that should support the heart—apparently play a role in disrupting the integrity of the organ's outermost layer, leaving patients vulnerable to sudden cardiac death.

The epicardium, the heart's outer cloak, hugs the myocardium—the contractile muscle—the inner and thickest layer of the organ.

Arrhythmogenic cardiomyopathy—ACM—is a heart condition characterized by ventricular arrhythmias typically beginning in adolescence or early adulthood. Arrhythmias refer to irregular heartbeats, which can be too slow or too fast. Miscued beats occur ...