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First Clinical Trial of Innovative Cancer Drug Targeting HSF1 Pathway Begins

Medical Xpress

Photo: Institute of Cancer Research

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The first cancer patients are to receive doses of an innovative new drug that targets a master regulatory pathway in cells, as part of a new clinical trial.

The drug, called NXP800, was discovered at The Institute of Cancer Research, London, and targets the pathway regulated by the HSF1 transcription factor.

HSFI is a 'master switch' in cells that controls the activity of a variety of genes—and its signaling is hijacked by a variety of cancers to support their growth and spread.

The phase I clinical trial is sponsored by oncology-focused biopharmaceutical ...