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Antidopaminergic Antiemetics Associated with Elevated Risk of Ischemic Stroke

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NewsMedical.net

Drugs known as antidopaminergic antiemetics (ADAs) that are widely used to relieve nausea and vomiting caused, for instance, by migraine, chemotherapy or radiotherapy, and after surgery are associated with an increased risk of ischemic stroke, finds a study published by The BMJ today.

The results show that all three ADAs studied (domperidone, metopimazine, and metoclopramide) were associated with an increased risk, especially in the first days of use, but the highest increase was found for metopimazine and metoclopramide. The researchers suggest that the potential action of ADAs on blood flow to the brain could explain this ...