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Chimeras Offer a New Way To Study Childhood Cancers In Mice

Medical Xpress

Photo:Whitehead Institute for Biomedical Research

In a new paper published March 5 in the journal Cell Stem Cell, researchers in Whitehead Institute Member Rudolph Jaenisch's lab introduce a new way to model human neuroblastoma tumors in mice using chimeras—in this case, mice that have been modified to have human cells in parts of their nervous systems. "This may serve as a unique model that you can use to study the dynamic of immune cells within human tumors," says Malkiel Cohen, a postdoc in Jaenisch's lab and the first author of the paper.


Neuroblastoma is ...