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Molds Damage the Lung’s Protective Barrier to Spur Future Asthma Attacks

News | UW-Madison

news.wisc.edu

University of Wisconsin–Madison researchers have identified a new way that common Aspergillus molds can induce asthma, by first attacking the protective tissue barrier deep in the lungs.

In both mice and humans, an especially strong response to this initial damage was associated with developing an overreaction to future mold exposure and the constricted airways characteristic of asthma.

The work provides a new avenue of research for understanding and potentially preventing the development of asthma, which affects 25 million Americans. Mold sensitivities account for a quarter to half of asthma responses, so preventing the body from establishing ...