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Triggering Melanoma Cell Death to Fight Cancer with its Own 'Suicide Switch'

Centenary Institute

centenary.org

Scientists at the Centenary Institute have reported a new strategy to battle melanoma, the most dangerous form of skin cancer, responsible for approximately 1,700 deaths in Australia each year.

Using drugs to inhibit two separate proteins, the researchers found that they could effectively kill melanoma cells by inducing apoptosis (the process of cellular self-destruction that takes place when a cell is no longer needed).

This new treatment strategy has the potential to benefit a subgroup of melanoma patients who do not respond to targeted therapies or immunotherapy.

"Provoking apoptosis has proven extremely difficult due to the high ...