Gut Bacteria Affecting Parkinson’s Treatment
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Parkinson’s disease (PD) is treated by levodopa, which is a prodrug capable of crossing the blood-brain barrier before being metabolized to dopamine, a vital neurotransmitter in the brain.
However, certain gut bacteria interfere with this treatment, leading to unpredictable fluctuations in the motor response to levodopa and pushing up the dosage levels unnecessarily.
The Gut-Brain Axis
The gut microbiome numbers trillions, which is an order of magnitude higher than the number of cells in the human body. It also contains 150 times more genes and its biomass is equivalent to the human ...