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Researchers Develop 'Poisoned Arrow' to Defeat Antibiotic-Resistant Bacteria

Photo: Matilda Luk, Princeton University Office of Communications

Poison is lethal all on its own—as are arrows—but their combination is greater than the sum of their parts. A weapon that simultaneously attacks from within and without can take down even the strongest opponents, from E. coli to MRSA (methicillin resistant Staphylococcus aureus).

A team of Princeton researchers reported today in the journal Cell that they have found a compound, SCH-79797, that can simultaneously puncture bacterial walls and destroy folate within their cells—while being immune to antibiotic resistance.

Bacterial infections come in two flavors—Gram-positive and ...