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Researchers Find Therapeutic Targets to Fight SARS-CoV-2

Phys.org

Credit: Nersisyan

Phys.org

Researchers from HSE University have developed new approaches for regulating the expression of ACE2 and TMPRSS2 enzymes, which play a crucial role in cell infection with SARS-CoV-2. The scholars discovered that small non-coding microRNA (miRNA) molecules are capable of performing a targeted decrease in ACE2 and TMPRSS2. The results of the study have been published in PLOS ONE.

Angiotensin-convertingenzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) enzymes act as entrance gates into the cell for the novel coronavirus. After successful penetration, the virus uses the cell's recourses to replicate and exit the cell to ...