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Researchers Identify Enzyme Linked to Colitis

Medical Xpress

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An enzyme that usually stops bacterial growth in the large intestine stimulates inflammation in some people, resulting in ulcerative colitis—a chronic digestive disease that affects more than 750,000 Americans, according to scientists at Rutgers University-Newark.

In a new study published in Immunity, lead author Nan Gao, Associate Professor of Cell Biology in the Department of Biological Sciences, School of Arts and Sciences-Newark, reports that in people with ulcerative colitis, the gut enzyme lysozyme which normally functions to restrain bacterial growth, instead stimulates inflammation.

This results in the formation of ulcers and sores in ...