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Caffeine May Offset Some Health Risks of Diets High in Fat, Sugar
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Targeting Plasmacytoid Dendritic Cells Can Reduce Cutaneous Lupus Symptoms

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Jodi Karnell and colleagues have developed a monoclonal antibody, VIB7734, that reduces symptom severity in people with cutaneous lupus by targeting and depleting plasmacytoid dendritic cells (pDC) in blood and skin. In two phase I clinical trials involving a total of 67 people with autoimmune diseases such as lupus, treatment with VIB7734 was as safe as a placebo and significantly reduced pDC frequencies, the researchers found. The antibody also reduced the activity of a group of key immune proteins called type 1 interferons in the skin. Both pDCs and type 1 interferons are suspected to play ...