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Could Arketamine Be a Breakthrough Therapy for Depression?

EU Healthcare & Social Care News

Ketamine has a fifty-year history in medicine. Discovered in 1962, ketamine is a psychoactive, dissociative drug that has commonly been used as a general anesthetic and sedative. Enantiomers (molecules that are mirror images of one another) of ketamine are esketamine and arketamine, and esketamine has recently received approval from the FDA as a therapy for treatment-resistant depression. Yet, the two molecules have subtle but important differences in how they act on the body.

Both compounds appear to be good potential antidepressants – however, arketamine has received little attention for its efficacy for the treatment of depression, despite showing promise ...