Researchers Develop 'Poisoned Arrow' to Defeat Antibiotic-Resistant Bacteria
Photo: Matilda Luk, Princeton University Office of Communications
Poison is lethal all on its own—as are arrows—but their combination is greater than the sum of their parts. A weapon that simultaneously attacks from within and without can take down even the strongest opponents, from E. coli to MRSA (methicillin resistant Staphylococcus aureus).
A team of Princeton researchers reported today in the journal Cell that they have found a compound, SCH-79797, that can simultaneously puncture bacterial walls and destroy folate within their cells—while being immune to antibiotic resistance.
Bacterial infections come in two flavors—Gram-positive and ...