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Adding Another Dimension to a Cell Culture Model for Pulmonary Arterial Hypertension

Medical Xpress

Photo: 2020 Mitsunobu R. Kano

MedicalXpress.com

Pulmonary arterial hypertension (PAH) is a rare--albeit deadly--disease that affects the arteries of the lung. In PAH, abnormal growth of cells of the vascular media--or the elastic wall--of the pulmonary arteries, called pulmonary arterial smooth muscle cells (PASMCs), results in thickening of the walls. This leads to the narrowing and/or obstruction of small pulmonary arteries, thus causing increased pulmonary vascular resistance and arterial pressure--ultimately leading to right heart failure. Over the years, various drugs have been approved for PAH treatment, but the survival of PAH patients three years after diagnosis still remains ...